• Home
  • Health & Wellness
  • Disclaimer
    • Terms of Use
    • Privacy Policy
    • DMCA Notice
Podcast
  • Home
  • Health & Wellness
  • Disclaimer
    • Terms of Use
    • Privacy Policy
    • DMCA Notice
24/7 Health News
No Result
View All Result
Home Article

Genetics might explain why some people have never had COVID – but we shouldn’t be too focused on finding out

February 9, 2023
in Article
0
Genetics might explain why some people have never had COVID – but we shouldn’t be too focused on finding out
file 20230206 29 p6o6gc

LL_studio/Shutterstock

It’s been over three years since the first known COVID infection. Since then, we’ve seen hundreds of millions of cases around the globe.

You’ve probably had it – at least once, if not multiple times – as has nearly everyone you know. As continued waves of infections arrive, fewer and fewer people have never caught COVID. But, even taking into account those who have had it and not realised, there are probably still some people out there who have managed to avoid the virus altogether (so far).

Last year, I wrote about people who had yet to be infected. Were they somehow immune? Did they possess some advantageous genetic mutation? Were they simply avoiding people and continuing to take precautions? Or had they just been lucky, and their time was inevitably going to come?

Unfortunately, we still don’t know why some people have managed to avoid COVID for so long. Science takes time. We saw research occur at unprecedented speed in 2020 to understand SARS-CoV-2 (the virus that causes COVID) and to develop treatments and vaccines. But that level of funding and collaboration is hard to sustain in a world with so many worthwhile areas of research.

That said, some research is looking in particular at whether a genetic element helps explain why certain people have never caught COVID. But while this research is important, we shouldn’t lose focus on those who are suffering from the disease and its longer-term effects.




Read more:
Haven’t had COVID yet? It could be more than just luck


Is immunity in the genes?

The COVID Human Genetic Effort, led by researchers in the US, has recruited people with known exposure to the virus, but who haven’t had it themselves. This includes, for example, healthcare workers or people who lived in a household with a confirmed case of COVID.

Scientists will be examining their DNA and looking for unusual mutations that may explain an apparent resistance to SARS-CoV-2 infection. This may be a mutation in the cellular receptors or enzymes needed for the virus to gain entry to our cells, or perhaps a mutation in a gene involved in the immune response to infection.

Studies that look to uncover anomalies in our DNA, termed genome-wide association studies, have already been able to identify genetic mutations that make some people resistant to other infections like HIV and norovirus (the winter vomiting bug). If we can identify the reasons people may be immune to a particular virus then, theoretically, that knowledge could be used to prevent the infection.

But is it really that simple? Despite our understanding of the genetic mutations that protect a lucky minority of people against norovirus, there’s no vaccine or treatment for this virus. And the infamous “CRISPR babies” (several children born in 2018 whose genomes had been edited in an attempt to make them immune to HIV), received criticism for dubious ethics, not to mention being illegal.

An illustration of DNA.
Genetic mutations might explain why some people have never caught COVID.
Billion Photos/Shutterstock

It’s possible that it’s not a mutation in one gene, but a combination of mutations in multiple genes, that render a small number of people immune to COVID. Targeting multiple genes without causing any unwanted side-effects can be tricky and would make it much harder to harness this knowledge for anti-COVID drugs.

But understanding the genetic mutations that make someone resistant to COVID could provide valuable insight into how SARS-CoV-2 infects people and causes disease. In other words, it may be interesting scientifically, but perhaps not clinically.

While it will be some time before we have answers from these studies, scientists do believe there is a small group of people who are naturally immune to SARS-CoV-2 owing to their genes.

Time to shift focus?

As scientists, we can become fixated on certain details of our research. It’s always important to remind ourselves that there are people on the other end of these infectious diseases.

Although SARS-CoV-2 continues to infect people across the world, and is constantly mutating and evolving into new variants, its severity has in general been greatly reduced thanks to effective vaccines.




Read more:
Hybrid immunity: a combination of vaccination and prior infection probably offers the best protection against COVID


At the same time, an estimated two million people in the UK report long COVID, of which nearly one-fifth have symptoms so severe the condition significantly limits their day-to-day activities.

While there are a few theories as to what contributes to long COVID, including microclots in the blood and chronic inflammation, we don’t really know why some people are affected and others are not. So perhaps our focus should shift from the genetic determinants of immunity to SARS-CoV-2 to exploring whether some people may have a genetic predisposition to a potentially life-altering chronic disease.

The Conversation

Lindsay Broadbent has previously received funding from The Wellcome Trust. She is a member of The Microbiology Society.

ShareTweetSharePin
Previous Post

Seven ways to protect your health when cooking with gas

Next Post

CBD is not a cure-all – here’s what science says about its real health benefits

Next Post
CBD is not a cure-all – here’s what science says about its real health benefits

CBD is not a cure-all – here's what science says about its real health benefits

Most Read

What causes stuttering? A speech pathology researcher explains the science and the misconceptions around this speech disorder

What causes stuttering? A speech pathology researcher explains the science and the misconceptions around this speech disorder

December 15, 2022
morning back pain

Morning Again Ache Trigger Is Not the Mattress

October 11, 2021
lower back pain relief exercises

5 decrease again ache aid workouts

October 11, 2021
3 years after legalization, we have shockingly little information about how it changed cannabis use and health harms

3 years after legalization, we have shockingly little information about how it changed cannabis use and health harms

October 15, 2021
Nasal vaccines promise to stop the COVID-19 virus before it gets to the lungs – an immunologist explains how they work

Nasal vaccines promise to stop the COVID-19 virus before it gets to the lungs – an immunologist explains how they work

December 14, 2022
bleeding in gum

When The Bleeding in gum Is Severe ?

October 11, 2021
Good Night Sleep

6 Causes of Good Evening Sleep

October 11, 2021

COVID vaccines: how one can pace up rollout in poorer international locations

October 5, 2021
Ten small changes you can make today to prevent weight gain

Ten small changes you can make today to prevent weight gain

October 12, 2021
Support and collaboration with health-care providers can help people make health decisions

Support and collaboration with health-care providers can help people make health decisions

December 16, 2021
Greece to make COVID vaccines mandatory for over-60s, but do vaccine mandates work?

Greece to make COVID vaccines mandatory for over-60s, but do vaccine mandates work?

December 1, 2021

Multiple sclerosis: the link with earlier infection just got stronger – new study

October 12, 2021
News of war can impact your mental health — here’s how to cope

Binge-eating disorder is more common than many realise, yet it’s rarely discussed – here’s what you need to know

December 2, 2022
Nurses’ attitudes toward COVID-19 vaccination for their children are highly influenced by partisanship, a new study finds

Nurses’ attitudes toward COVID-19 vaccination for their children are highly influenced by partisanship, a new study finds

December 2, 2022
Kick up your heels – ballroom dancing offers benefits to the aging brain and could help stave off dementia

Kick up your heels – ballroom dancing offers benefits to the aging brain and could help stave off dementia

January 3, 2023
How hot is too hot for the human body? Our lab found heat + humidity gets dangerous faster than many people realize

How hot is too hot for the human body? Our lab found heat + humidity gets dangerous faster than many people realize

July 6, 2022
The promise of repairing bones and tendons with human-made materials

The promise of repairing bones and tendons with human-made materials

January 4, 2022
As viral infections skyrocket, masks are still a tried-and-true way to help keep yourself and others safe

As viral infections skyrocket, masks are still a tried-and-true way to help keep yourself and others safe

December 14, 2022
How regulatory agencies, not the courts, are imposing COVID-19 vaccine mandates

How regulatory agencies, not the courts, are imposing COVID-19 vaccine mandates

October 24, 2021
Heart disease risk from saturated fats may depend on what foods they come from – new research

Heart disease risk from saturated fats may depend on what foods they come from – new research

November 29, 2021
Late night eating may cause greater weight gain – new research points to why

Late night eating may cause greater weight gain – new research points to why

October 12, 2022

10 Things I Learned During My Body Transformation

October 12, 2021

7 Health Benefits of Sweet Potatoes

October 12, 2021
Nobel prize: how chilli peppers helped researchers uncover how humans feel pain

Nobel prize: how chilli peppers helped researchers uncover how humans feel pain

October 12, 2021
How air filters can make COVID wards safer for patients and staff

How air filters can make COVID wards safer for patients and staff

December 1, 2021
GPs don’t give useful weight-loss advice – new study

GPs don’t give useful weight-loss advice – new study

December 16, 2022
Four ways to avoid gaining weight over the festive period – but also why you shouldn’t fret about it too much

Four ways to avoid gaining weight over the festive period – but also why you shouldn’t fret about it too much

December 22, 2022
Five ways to avoid pain and injury when starting a new exercise regime

Five ways to avoid pain and injury when starting a new exercise regime

December 30, 2022
Why suicide prevention support is crucial for people with fetal alcohol spectrum disorder

Why suicide prevention support is crucial for people with fetal alcohol spectrum disorder

September 28, 2022
Too hot to handle: Climate considerations for youth sport during the hottest years on record

Too hot to handle: Climate considerations for youth sport during the hottest years on record

July 19, 2022
  • Home
  • Health & Wellness
  • Disclaimer

© 2020 DAILY HEALTH NEWS

  • Home
  • Health & Wellness
  • Disclaimer
    • Terms of Use
    • Privacy Policy
    • DMCA Notice

© 2020 DAILY HEALTH NEWS