• Home
  • Health & Wellness
  • Disclaimer
    • Terms of Use
    • Privacy Policy
    • DMCA Notice
Podcast
  • Home
  • Health & Wellness
  • Disclaimer
    • Terms of Use
    • Privacy Policy
    • DMCA Notice
24/7 Health News
No Result
View All Result
Home Article

Speaking up for the annoying fruit fly

June 2, 2023
in Article
0
Speaking up for the annoying fruit fly
file 20230427 299 8ti3p5

vasekk/Shutterstock

Fruit flies can be truly annoying when they are buzzing around your living room or landing in your wine. But we have much to thank these tiny nuisances for – they revolutionised biological and medical science.

Flies and mosquitoes both belong to Diptera, the group of insects that have only two wings (from the Greek di meaning two and pteron meaning wing). However, just as most people accept the bothersome as well as the positive traits of their friends, we shouldn’t judge flies for their negative behaviour alone.

We should open our eyes to their enormous economic and environmental importance, as entomologist Erica McAlister argues in her book The Secret Life of Flies. For example, many plants (including the cacao plant that gives us chocolate) rely on Diptera as pollinators. Or try to imagine a world without flies to decompose dead animals.

I will argue from a different angle, though, to win your respect for one specific dipteran: the fruit or vinegar fly (Drosophila melanogaster).

Drosophila may be smaller than a fingernail but it can be a big nuisance in summer when it hovers over maturing fruit or emerges in swarms from litter bins. The species Drosophila was first mentioned by German entomologist Johann Meigen in 1830 and has since earned a celebrity status among scientists. It has become the best-understood animal organism on the planet and a powerhouse of modern medical research. Ten scientists working on Drosophila have been awarded a Nobel prize in physiology or medicine.

Science’s partnership with flies started during the early 1900s when biologist Thomas Hunt Morgan at Columbia University in New York decided to test evolutionary theories, such as how genetic mutations are linked to other characteristics, and the rediscovery in 1900 of Gregor Mendel’s theories of inheritance, published 1865. Mendel remains the acknowledged father of genetics today.

Helping science take off

Morgan was not the first to work with Drosophila. But his idea to harness the fly’s cheap husbandry (pieces of banana kept in milk bottles), and rapid reproduction (one generation in about ten days; about 100 eggs per female per day) would make it possible to study evolution in the laboratory. This is because it’s easier to see evolutionary changes in large populations of a species with high turnover.

His mass-breeding experiments with hundreds of thousands of flies led to the discovery of a single fly with white eyes, instead of the red eyes fruit flies normally have. Morgan and his team’s subsequent studies of its white-eyed progeny revealed that genes can mutate and are arranged into orderly and reproducible maps on chromosomes (a long DNA molecule). This new understanding founded the field of classical genetics as we know it. For example, it led to an understanding of how genetic disease is inherited.

In the 1940s, scientists, including George Beadle and Edward Tatum, established that some gene codes for proteins can facilitate chemical reactions and produce the molecules needed in cells.

Other researchers with fruit flies mapped the structure of the DNA helix. Through these developments, long-debated questions came into focus. For example, how genes regulate complex biological processes, such as the development of an entire organism from a single fertilised egg cell.

Scientists gradually established techniques using microscopes to study Drosophila embryos in their tiny 0.5mm transparent eggshells. The plethora of genetic strategies we’ve learned about in flies has turned into a powerful means to dissect mechanisms of fly development. Just like human gene mutations can cause body malformations in people, fly embryos also show such defects. For example, lacking their heads or tails.

Scientists can study mutant defects, even if the eggs never hatch, which can then inform us about the normal function of the affected gene. These kinds of genetic studies of Drosophila, combined with emerging technologies, such as gene cloning, helped us understand how gene networks can determine the development of a body and how they can sometimes cause inherited disorders. Gene networks are a set of genes, or parts of genes, that interact with each other to control a specific cell function. In 1995, three scientists won the Nobel prize for their contribution to this new understanding.

file 20230427 18 ohcdgk
Fruit flies and humans have surprisingly similar biology.
Andreas Prokop, Author provided

A startling likeness

Eventually, it emerged that the entire genomes of flies and humans showed astonishing similarities, and mechanisms or processes discovered in flies often turned out to apply to more complex organisms. Many human genes can even take over the function of their Drosophilia equivalent when inserted into the fly genome.

The common ancestor that founded the evolutionary lines of flies and humans, half a billion years ago, appears to have been equipped with biology so well-designed that many of its aspects are still maintained, such as mechanisms of growth or neuronal function. Because we are so alike genetically, many aspects of human biology and disease have been explored first in Drosophila. Meanwhile, research on fruit flies is fast, cost-effective and extremely versatile. It’s ideal for scientific discoveries.

Once knowledge has been gained in a fly, that knowledge can accelerate research in more complex organisms. Today, over 10,000 researchers worldwide are estimated to work with Drosophila in many areas of science that relate to human biology and disease. It is used by neuroscientists for studying learning, memory, sleep, aggression, addiction and neural disorders. Not to mention cancer and ageing, processes of development, the gut microbiome, stem cells, muscles and the heart.

That said, flies are not mini-humans. They cannot be used to study personality loss seen in Alzheimer’s disease, for example. But they can be used to study why neurons die in such diseases and bridge important gaps in our understanding of this type of disease.

Fruit flies hovering in your kitchen might be aggravating, but hopefully you will see them in a different light now.

The Conversation

Andreas Prokop received funding from The Welcome Trust and UKRI.

ShareTweetSharePin
Previous Post

‘Blue balls’: There’s no evidence they’re harmful, and they shouldn’t be used to pressure partners into sex

Next Post

Postnatal depression: what new fathers need to know – and how to ask for help

Next Post
Postnatal depression: what new fathers need to know – and how to ask for help

Postnatal depression: what new fathers need to know – and how to ask for help

Most Read

What causes stuttering? A speech pathology researcher explains the science and the misconceptions around this speech disorder

What causes stuttering? A speech pathology researcher explains the science and the misconceptions around this speech disorder

December 15, 2022
morning back pain

Morning Again Ache Trigger Is Not the Mattress

October 11, 2021
lower back pain relief exercises

5 decrease again ache aid workouts

October 11, 2021
3 years after legalization, we have shockingly little information about how it changed cannabis use and health harms

3 years after legalization, we have shockingly little information about how it changed cannabis use and health harms

October 15, 2021
bleeding in gum

When The Bleeding in gum Is Severe ?

October 11, 2021
Good Night Sleep

6 Causes of Good Evening Sleep

October 11, 2021
Nasal vaccines promise to stop the COVID-19 virus before it gets to the lungs – an immunologist explains how they work

Nasal vaccines promise to stop the COVID-19 virus before it gets to the lungs – an immunologist explains how they work

December 14, 2022

COVID vaccines: how one can pace up rollout in poorer international locations

October 5, 2021
Ten small changes you can make today to prevent weight gain

Ten small changes you can make today to prevent weight gain

October 12, 2021
Kick up your heels – ballroom dancing offers benefits to the aging brain and could help stave off dementia

Kick up your heels – ballroom dancing offers benefits to the aging brain and could help stave off dementia

January 3, 2023
Greece to make COVID vaccines mandatory for over-60s, but do vaccine mandates work?

Greece to make COVID vaccines mandatory for over-60s, but do vaccine mandates work?

December 1, 2021
Support and collaboration with health-care providers can help people make health decisions

Support and collaboration with health-care providers can help people make health decisions

December 16, 2021

Multiple sclerosis: the link with earlier infection just got stronger – new study

October 12, 2021
The promise of repairing bones and tendons with human-made materials

The promise of repairing bones and tendons with human-made materials

January 4, 2022
As viral infections skyrocket, masks are still a tried-and-true way to help keep yourself and others safe

As viral infections skyrocket, masks are still a tried-and-true way to help keep yourself and others safe

December 14, 2022
News of war can impact your mental health — here’s how to cope

Binge-eating disorder is more common than many realise, yet it’s rarely discussed – here’s what you need to know

December 2, 2022
GPs don’t give useful weight-loss advice – new study

GPs don’t give useful weight-loss advice – new study

December 16, 2022
Four ways to avoid gaining weight over the festive period – but also why you shouldn’t fret about it too much

Four ways to avoid gaining weight over the festive period – but also why you shouldn’t fret about it too much

December 22, 2022
Heart disease risk from saturated fats may depend on what foods they come from – new research

Heart disease risk from saturated fats may depend on what foods they come from – new research

November 29, 2021
How hot is too hot for the human body? Our lab found heat + humidity gets dangerous faster than many people realize

How hot is too hot for the human body? Our lab found heat + humidity gets dangerous faster than many people realize

July 6, 2022
Five ways to avoid pain and injury when starting a new exercise regime

Five ways to avoid pain and injury when starting a new exercise regime

December 30, 2022
How regulatory agencies, not the courts, are imposing COVID-19 vaccine mandates

How regulatory agencies, not the courts, are imposing COVID-19 vaccine mandates

October 24, 2021
Nurses’ attitudes toward COVID-19 vaccination for their children are highly influenced by partisanship, a new study finds

Nurses’ attitudes toward COVID-19 vaccination for their children are highly influenced by partisanship, a new study finds

December 2, 2022
Late night eating may cause greater weight gain – new research points to why

Late night eating may cause greater weight gain – new research points to why

October 12, 2022
How the relationships we have with plants contribute to human health in many ways

How the relationships we have with plants contribute to human health in many ways

October 29, 2021

10 Things I Learned During My Body Transformation

October 12, 2021
Chronic pain: An invisible disease whose sufferers are unfairly stigmatized

Chronic pain: An invisible disease whose sufferers are unfairly stigmatized

December 22, 2022
Better sleep for kids starts with better sleep for parents – especially after holiday disruptions to routines

Better sleep for kids starts with better sleep for parents – especially after holiday disruptions to routines

December 27, 2022
Too hot to handle: Climate considerations for youth sport during the hottest years on record

Too hot to handle: Climate considerations for youth sport during the hottest years on record

July 19, 2022
How to keep your pets safe in a heatwave

How to keep your pets safe in a heatwave

July 15, 2022
  • Home
  • Health & Wellness
  • Disclaimer

© 2020 DAILY HEALTH NEWS

  • Home
  • Health & Wellness
  • Disclaimer
    • Terms of Use
    • Privacy Policy
    • DMCA Notice

© 2020 DAILY HEALTH NEWS